HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Designing Randomized-Controlled Trials to Improve Head-Louse Treatment: Systematic Review Using a Vignette-Based Method

Abstract : Head-louse infestation remains a public health problem. Despite published randomized-controlled trials, no consensus-based clinical practice guidelines for its management emerged because of the heterogeneity of trial methodologies. Our study was undertaken to attempt to find an optimal trial framework: minimizing the risk of bias, while taking feasibility into account. To do so, we used the vignette-based method. A systematic review first identified trials on head-louse infestation; 49 were selected and their methodological constraints assessed. Methodological features were extracted and combined by arborescence to generate a broad spectrum of potential designs, called vignettes, yielding 357 vignettes. A panel of 48 experts then rated one-on-one comparisons of those vignettes to obtain a ranking of the designs. Methodological items retained for vignette generation were income level of the population, types of treatments compared, randomization unit, blinding, treatment-administration site, diagnosis method and criteria, and primary outcome measure. The expert panel selected vignettes with cluster randomization, centralized treatment administration, and blinding of the outcome assessor. The vignette method identified optimal designs to standardize future head-louse treatment trials, thereby obtaining valid conclusions and comparable data from future trials, and appears to be a reliable way to generate evidence-based guidelines.
Document type :
Journal articles
Complete list of metadata

Contributor : Scd Ehesp Connect in order to contact the contributor
Submitted on : Tuesday, April 5, 2022 - 12:03:49 PM
Last modification on : Wednesday, April 6, 2022 - 3:01:53 AM

Links full text




Giao Do-Pham, Laurence Le Cleach, Bruno Giraudeau, Annabel Maruani, Olivier Chosidow, et al.. Designing Randomized-Controlled Trials to Improve Head-Louse Treatment: Systematic Review Using a Vignette-Based Method. Journal of Investigative Dermatology, Nature Publishing Group, 2014, 134 (3), pp.628-634. ⟨10.1038/jid.2013.414⟩. ⟨hal-03630844⟩



Record views