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Emergence of Epidemic Neisseria meningitidis Serogroup X Meningitis in Togo and Burkina Faso

Abstract : Serogroup X meningococci (NmX) historically have caused sporadic and clustered meningitis cases in sub-Saharan Africa. To study recent NmX epidemiology, we analyzed data from population-based, sentinel and passive surveillance, and outbreak investigations of bacterial meningitis in Togo and Burkina Faso during 2006-2010. Cerebrospinal fluid specimens were analyzed by PCR. In Togo during 2006-2009, NmX accounted for 16% of the 702 confirmed bacterial meningitis cases. Kozah district experienced an NmX outbreak in March 2007 with an NmX seasonal cumulative incidence of 33/100,000. In Burkina Faso during 2007-2010, NmX accounted for 7% of the 778 confirmed bacterial meningitis cases, with an increase from 2009 to 2010 (4% to 35% of all confirmed cases, respectively). In 2010, NmX epidemics occurred in northern and central regions of Burkina Faso; the highest district cumulative incidence of NmX was estimated as 130/100,000 during March-April. Although limited to a few districts, we have documented NmX meningitis epidemics occurring with a seasonal incidence previously only reported in the meningitis belt for NmW135 and NmA, which argues for development of an NmX vaccine.
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Submitted on : Tuesday, June 8, 2021 - 3:00:41 PM
Last modification on : Wednesday, January 26, 2022 - 3:41:38 AM
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Isabelle Delrieu, Seydou Yaro, Tsidi a S Tamekloé, Berthe-Marie Njanpop-Lafourcade, Haoua Tall, et al.. Emergence of Epidemic Neisseria meningitidis Serogroup X Meningitis in Togo and Burkina Faso. PLoS ONE, Public Library of Science, 2011, 6 (5), pp.e19513. ⟨10.1371/journal.pone.0019513⟩. ⟨hal-03034656⟩

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