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Impact of vaccination on carriage of and infection by antibiotic-resistant bacteria: a systematic review and meta-analysis

Abstract : This systematic review and meta-analysis aims to quantify the impact of vaccination on the incidence and prevalence of nonsusceptible infections and investigates the impact of vaccination programs on serotype replacement. We searched a comprehensive set of databases. Identified studies were assessed using the GRADE (Grading of Recommendations Assess-ment, Development and Evaluation) approach and resulting evidence was analyzed using random-effect meta-analyses. Nineteen studies on pneumococcal conjugate vaccines (PCV) met our inclusion criteria. PCV decreases the incidence of nonsusceptible pneumococcal infections (PIs) by 56.91% (95% confidence interval [CI],-50.90% to-62.91%) and the probability of carriage of nonsusceptible pneumococcal bacteria by 28.10% (95% CI,-13.25% to-42.95%). The effect of PCV on PIs becomes higher when only serotypes specifically targeted by the vaccine are taken into account (-80.98%; 95% CI,-70.34% to-91.52%), while it becomes lower when all the PIs, including both susceptible and nonsusceptible PIs, are considered (-48.30%; 95% CI,-31.55% to-65.08%). The effect of PCV is found greater in populations with high prevalence of human immunodeficiency virus and for PCV covering a higher number of serotypes. Findings from this study suggest that vaccination programs may be an effective tool to prevent the spread of PIs and may play a significant role in tackling antimicrobial resistance
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https://hal.ehesp.fr/hal-03707801
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Submitted on : Tuesday, June 28, 2022 - 4:54:10 PM
Last modification on : Wednesday, June 29, 2022 - 3:15:38 AM

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Li Min Wang, Tiago Cravo Oliveira Hashiguchi, Michele Cecchini. Impact of vaccination on carriage of and infection by antibiotic-resistant bacteria: a systematic review and meta-analysis. Clinical and Experimental Vaccine Research, Korean Vaccine Society, 2021, 10 (2), pp.81. ⟨10.7774/CEVR.2021.10.2.81⟩. ⟨hal-03707801⟩

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