HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Study of a Localized Meningococcal Meningitis Epidemic in Burkina Faso: Incidence, Carriage, and Immunity

Judith E. Mueller 1, * Seydou Yaro 2 Berthe-Marie Njanpop-Lafourcade 1 Aly Drabo 2 Régina S. Idohou 1 Sita S. Kroman 1 Oumarou Sanou 1 Serge Diagbouga 2 Yves Traoré Lassana Sangaré Raymond Borrow Bradford D. Gessner 1
* Corresponding author
1 Agence de Médecine Préventive
2 Centre Muraz [Bobo-Dioulasso, Burkina Faso]
Abstract : Background. To better understand localized meningococcal meningitis epidemics, we evaluated a serogroup A (NmA) epidemic in Burkina Faso by surveillance, carriage, and seroprevalence studies. Methods. During March–April 2006, cerebrospinal fluid samples from patients suspected to have meningitis in 3 epidemic villages were analyzed by culture or polymerase chain reaction. We assessed meningococcal carriage and serogroup-specific serum bactericidal antibody titers with baby rabbit complement (rSBA) in a representative population sample (N = 624; age range, 1–39 years). A serogroup A/C polysaccharide vaccine campaign occurred in parallel. Results. Cumulative incidence of Nm meningitis was 0.45% and varied among villages (0.08%–0.91%). NmA carriage prevalence was 16% without variation by vaccination status. NmA carriage and anti-NmA seroprevalence varied by village and incidence. In the 2 villages with highest incidence and seroprevalence, presence of rSBA titers ≥8 was associated with NmA carriage (odds ratio [OR], 9.33 [95% confidence interval {CI}, 1.90–45.91]) and vaccination ≤4 days earlier (OR, 0.10 [95% CI, .03–.32]). Visibly purulent or Nm meningitis was significantly associated with recent flulike symptoms and exposure to kitchen smoke (risk ratios >15). Conclusions. A surge of NmA carriage may be involved in the development of meningococcal epidemics and rapidly increase anti-NmA seroprevalence. Flulike infection and kitchen smoke may contribute to the strength of epidemics.
Keywords : Polymerase chain reaction Meningitis Burkina faso Dsease transmission Immunity Meningococcal meningitis Omega-n-methylarginine Polysaccharides Smoke Vaccination Vaccines Epidemics Surveillance Seroprevalence Serogroup
Document type :
Journal articles
Complete list of metadata
https://hal.ehesp.fr/hal-03034645
Contributor : Scd Ehesp Connect in order to contact the contributor
Submitted on : Tuesday, December 1, 2020 - 7:13:15 PM
Last modification on : Wednesday, December 2, 2020 - 3:28:25 AM

Links full text

pubmedcentral

Identifiers

Collections

EHESP | METIS-EHESP | USPC

Citation

Judith E. Mueller, Seydou Yaro, Berthe-Marie Njanpop-Lafourcade, Aly Drabo, Régina S. Idohou, et al.. Study of a Localized Meningococcal Meningitis Epidemic in Burkina Faso: Incidence, Carriage, and Immunity. Journal of Infectious Diseases, Oxford University Press (OUP), 2011, 204 (11), pp.1787-1795. ⟨10.1093/infdis/jir623⟩. ⟨hal-03034645⟩

Export

BibTeX TEI DC DCterms EndNote Datacite

Share

Metrics

Record views

61