Scientific literature from EHESP School of Public Health

Journal articles

Immunization and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society

C. Lebrun ¹ S. Vukusic ^{2, 3, *} V. Abadie C. Achour F. Ader ⁴ H. Alchaar A. Alkhedr F. Andreux ⁵ G. Androdias R. Arjmand Bertrand Audoin ⁶ D. Audry D. Aufauvre C. Autreaux X. Ayrignac ⁷ M. Bailbe M. Benazet C. Bensa D. Bensmail Eric Berger P. Bernady Y. Bertagna D. Biotti A. Blanchard-Dauphin Jérémie Bonenfant ⁸ M. Bonnan B. Bonnemain F. Borgel E. Botelho-Nevers ⁹ S. Boucly Bertrand Bourre C. Boutière ¹⁰ P. Branger D. Brassat ⁶ S. Bresch ¹¹ V. Breuil ¹² Bruno Brochet ⁶ H. Brugeilles P. Bugnon Philippe Cabre Jean-Philippe Camdessanché C. Carra-Dalière Olivier Casez J.-M. Chamouard B. Chassande P. Chataignier M. Chbicheb A. Chenet ¹³ Jonathan Ciron Pierre Clavelou ⁶ M. Cohen ¹⁴ R. Colamarino N. Collongues ⁶ I. Coman P.-R. Corail S. Courtois M. Coustans ¹⁵ Alain Créange ¹⁶ E. Creisson N. Daluzeau C. Davenas J. de Seze ⁶ Marc Debouverie ¹⁷ R. Depaz N. Derache L. Divio X. Douay C. Dulau F. Durand-Dubief ¹⁸ G. Edan ¹⁵ Z. Elias O. Fagniez M. Faucher J.-M. Faucheux M. Fournier ¹⁹ A. Gagneux-Brunon ⁹ P. Gaida P. Galli P. Gallien J. Gaudelus ²⁰ D. Gault ²¹ A. Gayou M. Genevray A. Gentil J. Gere L. Gignoux M. Giroux P. Givron O. Gout ²² J. Grimaud A.-M. Guennoc N. Hadhoum P. Hautecoeur Olivier Heinzlef M. Jaeger S. Jeannin L. Kremer ²³ A. Kwiatkowski Pierre Labauge ⁶ Céline Labeyrie S. Lachaud I. Laffont ²⁴ C. Lanctin-Garcia J. Lannoy L. Lanotte David A. Laplaud ²⁵ D. Latombe M. Lauxerois Emmanuelle Le Page ⁸ Christine Lebrun-Frenay ²⁶ P. Lejeune P. Lejoyeux B. Lemonnier Emmanuelle Leray ^{27, 28, 29} C.-M. Loche C. Louapre ³⁰ Catherine Lubetzki ³¹ A. Maarouf ⁶ B. Mada L. Magy ⁶ E. Maillart ³² E. Manchon R. Marignier ³ P. Marque G. Mathey ¹⁷ A. Maurousset C. Mekies M. Merienne ²³ L. Michel A.-M. Milor X. Moisset ³³ Alexis Montcuquet Thibault Moreau N. Morel M. Moussa J.-P. Naudillon M. Normand P. Olive J.-C. Ouallet Olivier Outteryck C. Pacault C. Papeix ³² Ivania Patry ³⁴ D. Peaureaux Jean Pelletier ³⁵ B. Pichon ³⁶ S. Pittion E. Planque M.-C. Pouget V. Pourcher ³⁷ C. Radot I. Robert F. Rocher A. Ruet ³⁸ C. Saint-Val J.-Y. Salle A. Salmon E. Sartori S. Schaeffer B. Stankhof F. Taithe ³⁹ Eric Thouvenot ⁶ C. Tizon Ayman Tourbah ⁴⁰ P. Tourniaire M. Vaillant ⁴¹ Patrick Vermersch ⁶ S. Vidil A. Wahab M.-H. Warter S. Wiertlewski ⁴² B. Wiplosz B. Wittwer C. Zaenker H. Zephir ⁶

* Corresponding author

1 UCA - Université Côte d'Azur

2 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]

3 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center

4 Hosp Civils Lyon, Serv Malad Infect, Lyon, France

5 BGS - Biogéosciences [UMR 6282]

6 CRMBM - Centre de résonance magnétique biologique et médicale

7 CHU Montpellier

8 CHU Pontchaillou [Rennes]

9 CHU Saint-Etienne

10 CEMEREM - Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - AP-HM]

11 Comité de Développement Horticole du Centre Val de Loire (CDHRC)

12 GéPITOS - Génétique, physiopathologie et ingénierie du tissu osseux

13 SECM - Service d'Etudes du Comportement des Matériaux de Conditionnement

14 GEPI - Galaxies, Etoiles, Physique, Instrumentation

15 Service de Neurologie [Rennes] = Neurology [Rennes]

16 ENT - Excitabilité nerveuse et thérapeutique

17 APEMAC - Maladies chroniques, santé perçue, et processus d'adaptation

18 RMN et optique : De la mesure au biomarqueur

CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé

19 Combustion Research Facility

20 Service de Pédiatrie [Jean Verdier]

21 Kuriwa Observatory

22 Fondation Ophtalmologique Adolphe de Rothschild [Paris]

23 IBCP - Institut de biologie et chimie des protéines [Lyon]

24 EuroMov - Euromov

25 U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie

26 UNS UFR Médecine - Université Nice Sophia Antipolis - Faculté de Médecine

27 REPERES - Recherche en Pharmaco-épidémiologie et Recours aux Soins

28 EHESP - École des Hautes Études en Santé Publique [EHESP]

29 METIS - Département Méthodes quantitatives en santé publique

30 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute

31 Biologie des Interactions Neurones / Glie

32 Service de Neurologie [CHU Pitié-Salpêtrière]

33 Service de Neurologie [CHU Clermont-Ferrand]

34 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon

35 LAGEP - Laboratoire d'automatique et de génie des procédés

36 UL - Université de Lorraine

37 CHU Pitié-Salpêtrière [AP-HP]

38 Haras National Suisse

39 CHU Clermont-Ferrand

40 CHU Reims - Centre Hospitalier Universitaire de Reims

41 Center for health studies

42 Service de neurologie [Nantes]

Abstract : Objectives: To establish recommendations on immunization for patients with multiple sclerosis (MS).Background: Vaccines have been suspected in the past to trigger MS and relapses. With the extension of the immunoactive treatment arsenal, other concerns have been raised more recently about an increased risk of infection or a decreased effectiveness of immunization in immunosuppressed patients.Methods: The French Group for Recommendations into Multiple Sclerosis (France4MS) performed a systematic search of papers in Medline and other university databases (January 1975-June 2018). The RAND/UCLA appropriateness method was chosen to review the scientific literature and to formalize the degree of agreement among experts on 5 clinical questions related to immunization and MS. Readers from the steering committee conducted a systematic analysis, wrote a critical synthesis and prepared a list of proposals that were evaluated by a rating group of 28 MS experts. The final version of the recommendations was finally reviewed by a reading group of 110 health care professionals and classified as appropriate, inappropriate or uncertain.Results: Neurologists should verify the vaccination status as soon as MS is diagnosed and before disease-modifying treatments (DMTs) are introduced. The French vaccination schedule applies to MS patients and seasonal influenza vaccination is recommended. In the case of treatment-induced immunosuppression, MS patients should be informed about the risk of infection and the vaccination standards of the French High Council of Health should be applied. Live attenuated vaccines are contra-indicated in patients recently treated with immunosuppressive drugs, including corticosteroids; other vaccines can be proposed whatever the treatment, but their effectiveness may be partly reduced with some drugs.Conclusion: Physicians and patients should be aware of the updated recommendations for immunizations of patients with MS.

Keywords : Prevention Multiple sclerosis Immunization Infection Vaccine

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Santé publique et épidémiologie

Complete list of metadata

https://hal.ehesp.fr/hal-02546158
Contributor : SCD EHESP Connect in order to contact the contributor
Submitted on : Friday, April 17, 2020 - 5:14:19 PM
Last modification on : Saturday, September 24, 2022 - 3:04:06 PM