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Immunization and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society

C. Lebrun S. Vukusic 1 V. Abadie C. Achour F. Ader 2 H. Alchaar A. Alkhedr F. Andreux 3 G. Androdias R. Arjmand B. Audoin 4 D. Audry D. Aufauvre C. Autreaux X. Ayrignac 5 M. Bailbe M. Benazet C. Bensa D. Bensmail E. Berger P. Bernady Y. Bertagna D. Biotti A. Blanchard-Dauphin J. Bonenfant 6 M. Bonnan B. Bonnemain F. Borgel E. Botelho-Nevers 7 S. Boucly B. Bourre C. Boutière 8 P. Branger D. Brassat 4 S. Bresch 9 V. Breuil 10 B. Brochet 4 H. Brugeilles P. Bugnon P. Cabre J.-P. Camdessanché C. Carra-Dalière O. Casez J.-M. Chamouard B. Chassande P. Chataignier M. Chbicheb A. Chenet 11 J. Ciron P. Clavelou 4 M. Cohen 12 R. Colamarino N. Collongues 4 I. Coman P.-R. Corail S. Courtois M. Coustans 13 A. Créange 14 E. Creisson N. Daluzeau C. Davenas J. de Seze 4 M. Debouverie 15 R. Depaz N. Derache L. Divio X. Douay C. Dulau F. Durand-Dubief 16 G. Edan 13 Z. Elias O. Fagniez M. Faucher J.-M. Faucheux M. Fournier 17 A. Gagneux-Brunon 7 P. Gaida P. Galli P. Gallien J. Gaudelus 18 D. Gault 19 A. Gayou M. Genevray A. Gentil J. Gere L. Gignoux M. Giroux P. Givron O. Gout 20 J. Grimaud A.-M. Guennoc N. Hadhoum P. Hautecoeur O. Heinzlef M. Jaeger 21 S. Jeannin L. Kremer 22 A. Kwiatkowski P. Labauge 4 C. Labeyrie S. Lachaud I. Laffont 23 C. Lanctin-Garcia J. Lannoy L. Lanotte D. Laplaud 24 D. Latombe M. Lauxerois E. Le Page 6 C. Lebrun-Frenay 25 P. Lejeune P. Lejoyeux B. Lemonnier Emmanuelle Leray 26, 27, 28 C.-M. Loche C. Louapre 29 C. Lubetzki 30 A. Maarouf 4 B. Mada L. Magy 4 E. Maillart 31 E. Manchon R. Marignier 32 P. Marque G. Mathey 15 A. Maurousset C. Mekies M. Merienne 22 L. Michel 33 A.-M. Milor X. Moisset 34 A. Montcuquet T. Moreau N. Morel M. Moussa J.-P. Naudillon M. Normand P. Olive J.-C. Ouallet O. Outteryck C. Pacault C. Papeix 31 I. Patry 35 D. Peaureaux J. Pelletier 36 B. Pichon 37 S. Pittion E. Planque M.-C. Pouget V. Pourcher 38 C. Radot I. Robert F. Rocher A. Ruet 39 C. Saint-Val J.-Y. Salle A. Salmon E. Sartori S. Schaeffer B. Stankhof F. Taithe 40 E. Thouvenot 4 C. Tizon A. Tourbah 41 P. Tourniaire M. Vaillant 42 P. Vermersch 4 S. Vidil A. Wahab M.-H. Warter S. Wiertlewski 43 B. Wiplosz B. Wittwer C. Zaenker H. Zephir 4
1 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
2 Hosp Civils Lyon, Serv Malad Infect, Lyon, France
3 BGS - Biogéosciences [UMR 6282] [Dijon]
4 CRMBM - Centre de résonance magnétique biologique et médicale
5 CHU Montpellier
6 CHU Pontchaillou [Rennes]
7 CHU Saint-Etienne
8 CEMEREM - Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - AP-HM]
9 Comité de Développement Horticole du Centre Val de Loire (CDHRC)
10 GéPITOS - Génétique, physiopathologie et ingénierie du tissu osseux
11 SECM - Service d'Etudes du Comportement des Matériaux de Conditionnement
12 GEPI - Galaxies, Etoiles, Physique, Instrumentation
13 Service de Neurologie [Rennes]
14 ENT - Excitabilité nerveuse et thérapeutique
15 APEMAC - Maladies chroniques, santé perçue, et processus d'adaptation
16 RMN et optique : De la mesure au biomarqueur
CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
17 Combustion Research Facility
18 Service de Pédiatrie [Jean Verdier]
19 Kuriwa Observatory
20 Fondation Ophtalmologique Adolphe de Rothschild [Paris]
21 M2P2 - Laboratoire de Mécanique, Modélisation et Procédés Propres
22 IBCP - Institut de biologie et chimie des protéines [Lyon]
23 EuroMov - Euromov
24 U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie
25 UNS UFR Médecine - Université Nice Sophia Antipolis - Faculté de Médecine
26 REPERES - Recherche en Pharmaco-épidémiologie et Recours aux Soins
27 EHESP - École des Hautes Études en Santé Publique [EHESP]
28 METIS - Département Méthodes quantitatives en santé publique
29 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
30 Biologie des Interactions Neurones / Glie
31 Département de Neurologie [Paris]
32 CRNL - Centre de recherche en neurosciences de Lyon
33 CIC - Centre d'Investigation Clinique [Rennes]
34 Service de Neurologie, CHU Clermont-Ferrand
35 Hôpital Jean Minjoz
36 LAGEP - Laboratoire d'automatique et de génie des procédés
37 UL - Université de Lorraine
38 CHU Pitié-Salpêtrière [AP-HP]
39 Haras National Suisse
40 CHU Clermont-Ferrand
41 CHU Reims - Centre Hospitalier Universitaire de Reims
42 Center for health studies
43 Service de neurologie [Nantes]
Abstract : Objectives: To establish recommendations on immunization for patients with multiple sclerosis (MS).Background: Vaccines have been suspected in the past to trigger MS and relapses. With the extension of the immunoactive treatment arsenal, other concerns have been raised more recently about an increased risk of infection or a decreased effectiveness of immunization in immunosuppressed patients.Methods: The French Group for Recommendations into Multiple Sclerosis (France4MS) performed a systematic search of papers in Medline and other university databases (January 1975-June 2018). The RAND/UCLA appropriateness method was chosen to review the scientific literature and to formalize the degree of agreement among experts on 5 clinical questions related to immunization and MS. Readers from the steering committee conducted a systematic analysis, wrote a critical synthesis and prepared a list of proposals that were evaluated by a rating group of 28 MS experts. The final version of the recommendations was finally reviewed by a reading group of 110 health care professionals and classified as appropriate, inappropriate or uncertain.Results: Neurologists should verify the vaccination status as soon as MS is diagnosed and before disease-modifying treatments (DMTs) are introduced. The French vaccination schedule applies to MS patients and seasonal influenza vaccination is recommended. In the case of treatment-induced immunosuppression, MS patients should be informed about the risk of infection and the vaccination standards of the French High Council of Health should be applied. Live attenuated vaccines are contra-indicated in patients recently treated with immunosuppressive drugs, including corticosteroids; other vaccines can be proposed whatever the treatment, but their effectiveness may be partly reduced with some drugs.Conclusion: Physicians and patients should be aware of the updated recommendations for immunizations of patients with MS.
Keywords : Vaccine Prevention Immunization Infection Multiple sclerosis
Document type :
Journal articles
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https://hal.ehesp.fr/hal-02546158
Contributor : Scd Ehesp <>
Submitted on : Friday, April 17, 2020 - 5:14:19 PM
Last modification on : Thursday, January 14, 2021 - 4:20:03 PM

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EHESP | REPERES | UNIV-RENNES1 | METIS-EHESP | UNIV-BOURGOGNE | HCL | OBSPM | EC-MARSEILLE | CRMBM | CHLS | ENT | M2P2 | CREATIS | UPEC-UPEM | UPEC | CIC | CEA | UNIV-LORRAINE | UNIV-ST-ETIENNE | UNIV-LYON1 | CIC203 | UR1-UFR-SVE | ICM | INSA-LYON | UNIV-MONTPELLIER | UNICE | UNIV-COTEDAZUR | UNIV-NANTES | UNIV-RENNES | CRTI | APEMAC-UL | LAGEP | UNIV-AMU | INSA-GROUPE | SORBONNE-UNIVERSITE | SU-MEDECINE | USPC | CNRS | UDL | UNIV-PARIS13 | BS | UNIV-PARIS7 | INSU | BIOSIT | UNIV-PARIS | PSL | BMS-UL

Citation

C. Lebrun, S. Vukusic, V. Abadie, C. Achour, F. Ader, et al.. Immunization and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society. Revue Neurologique, Elsevier Masson, 2019, 175 (6), pp.341-357. ⟨10.1016/j.neurol.2019.04.001⟩. ⟨hal-02546158⟩

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