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Immunization and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society

C. Lebrun S. Vukusic 1 V. Abadie C. Achour F. Ader 2 H. Alchaar A. Alkhedr F. Andreux 3 G. Androdias R. Arjmand B. Audoin 4 D. Audry D. Aufauvre C. Autreaux X. Ayrignac 5 M. Bailbe M. Benazet C. Bensa D. Bensmail E. Berger P. Bernady Y. Bertagna D. Biotti A. Blanchard-Dauphin J. Bonenfant 6 M. Bonnan B. Bonnemain F. Borgel E. Botelho-Nevers 7 S. Boucly B. Bourre C. Boutière 8 P. Branger D. Brassat 4 S. Bresch 9 V. Breuil 10 B. Brochet 4 H. Brugeilles P. Bugnon P. Cabre J.-P. Camdessanché C. Carra-Dalière O. Casez J.-M. Chamouard B. Chassande P. Chataignier M. Chbicheb A. Chenet 11 J. Ciron P. Clavelou 4 M. Cohen 12 R. Colamarino N. Collongues 4 I. Coman P.-R. Corail S. Courtois M. Coustans 13 A. Créange 14 E. Creisson N. Daluzeau C. Davenas J. de Seze 4 M. Debouverie 15 R. Depaz N. Derache L. Divio X. Douay C. Dulau F. Durand-Dubief 16 G. Edan 13 Z. Elias O. Fagniez M. Faucher J.-M. Faucheux M. Fournier 17 A. Gagneux-Brunon 7 P. Gaida P. Galli P. Gallien J. Gaudelus 18 D. Gault 19 A. Gayou M. Genevray A. Gentil J. Gere L. Gignoux M. Giroux P. Givron O. Gout 20 J. Grimaud A.-M. Guennoc N. Hadhoum P. Hautecoeur O. Heinzlef M. Jaeger 21 S. Jeannin L. Kremer 22 A. Kwiatkowski P. Labauge 4 C. Labeyrie S. Lachaud I. Laffont 23 C. Lanctin-Garcia J. Lannoy L. Lanotte D. Laplaud 24 D. Latombe M. Lauxerois E. Le Page 6 C. Lebrun-Frenay 25 P. Lejeune P. Lejoyeux B. Lemonnier Emmanuelle Leray 26, 27, 28 C.-M. Loche C. Louapre 29 C. Lubetzki 30 A. Maarouf 4 B. Mada L. Magy 4 E. Maillart 31 E. Manchon R. Marignier 32 P. Marque G. Mathey 15 A. Maurousset C. Mekies M. Merienne 22 L. Michel 33 A.-M. Milor X. Moisset 34 A. Montcuquet T. Moreau N. Morel M. Moussa J.-P. Naudillon M. Normand P. Olive J.-C. Ouallet O. Outteryck C. Pacault C. Papeix 31 I. Patry 35 D. Peaureaux J. Pelletier 36 B. Pichon 37 S. Pittion E. Planque M.-C. Pouget V. Pourcher 38 C. Radot I. Robert F. Rocher A. Ruet 39 C. Saint-Val J.-Y. Salle A. Salmon E. Sartori S. Schaeffer B. Stankhof F. Taithe 40 E. Thouvenot 4 C. Tizon A. Tourbah 41 P. Tourniaire M. Vaillant 42 P. Vermersch 4 S. Vidil A. Wahab M.-H. Warter S. Wiertlewski 43 B. Wiplosz B. Wittwer C. Zaenker H. Zephir 4
16 RMN et optique : De la mesure au biomarqueur
CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
Abstract : Objectives: To establish recommendations on immunization for patients with multiple sclerosis (MS).Background: Vaccines have been suspected in the past to trigger MS and relapses. With the extension of the immunoactive treatment arsenal, other concerns have been raised more recently about an increased risk of infection or a decreased effectiveness of immunization in immunosuppressed patients.Methods: The French Group for Recommendations into Multiple Sclerosis (France4MS) performed a systematic search of papers in Medline and other university databases (January 1975-June 2018). The RAND/UCLA appropriateness method was chosen to review the scientific literature and to formalize the degree of agreement among experts on 5 clinical questions related to immunization and MS. Readers from the steering committee conducted a systematic analysis, wrote a critical synthesis and prepared a list of proposals that were evaluated by a rating group of 28 MS experts. The final version of the recommendations was finally reviewed by a reading group of 110 health care professionals and classified as appropriate, inappropriate or uncertain.Results: Neurologists should verify the vaccination status as soon as MS is diagnosed and before disease-modifying treatments (DMTs) are introduced. The French vaccination schedule applies to MS patients and seasonal influenza vaccination is recommended. In the case of treatment-induced immunosuppression, MS patients should be informed about the risk of infection and the vaccination standards of the French High Council of Health should be applied. Live attenuated vaccines are contra-indicated in patients recently treated with immunosuppressive drugs, including corticosteroids; other vaccines can be proposed whatever the treatment, but their effectiveness may be partly reduced with some drugs.Conclusion: Physicians and patients should be aware of the updated recommendations for immunizations of patients with MS.
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Submitted on : Friday, April 17, 2020 - 5:14:19 PM
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C. Lebrun, S. Vukusic, V. Abadie, C. Achour, F. Ader, et al.. Immunization and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society. Revue Neurologique, Elsevier Masson, 2019, 175 (6), pp.341-357. ⟨10.1016/j.neurol.2019.04.001⟩. ⟨hal-02546158⟩

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