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Immunization and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society

C. Lebrun S. Vukusic 1 V. Abadie C. Achour F. Ader 2 H. Alchaar A. Alkhedr F. Andreux 3 G. Androdias R. Arjmand B. Audoin 4 D. Audry D. Aufauvre C. Autreaux X. Ayrignac 5 M. Bailbe M. Benazet C. Bensa D. Bensmail E. Berger P. Bernady Y. Bertagna D. Biotti A. Blanchard-Dauphin J. Bonenfant 6 M. Bonnan B. Bonnemain F. Borgel E. Botelho-Nevers 7 S. Boucly B. Bourre C. Boutière 8 P. Branger D. Brassat 4 S. Bresch 9 V. Breuil 10 B. Brochet 4 H. Brugeilles P. Bugnon P. Cabre J.-P. Camdessanché C. Carra-Dalière O. Casez J.-M. Chamouard B. Chassande P. Chataignier M. Chbicheb A. Chenet 11 J. Ciron P. Clavelou 4 M. Cohen 12 R. Colamarino N. Collongues 4 I. Coman P.-R. Corail S. Courtois M. Coustans 13 A. Créange 14 E. Creisson N. Daluzeau C. Davenas J. de Seze 4 M. Debouverie 15 R. Depaz N. Derache L. Divio X. Douay C. Dulau F. Durand-Dubief 16 G. Edan 13 Z. Elias O. Fagniez M. Faucher 17 J.-M. Faucheux M. Fournier 18 A. Gagneux-Brunon 7 P. Gaida P. Galli P. Gallien J. Gaudelus 19 D. Gault 20 A. Gayou M. Genevray A. Gentil J. Gere L. Gignoux M. Giroux P. Givron O. Gout 21 J. Grimaud A.-M. Guennoc N. Hadhoum P. Hautecoeur O. Heinzlef M. Jaeger 22 S. Jeannin L. Kremer 23 A. Kwiatkowski P. Labauge 4 C. Labeyrie S. Lachaud I. Laffont 24 C. Lanctin-Garcia J. Lannoy L. Lanotte D. Laplaud 25 D. Latombe M. Lauxerois E. Le Page 6 C. Lebrun-Frenay 26 P. Lejeune P. Lejoyeux B. Lemonnier Emmanuelle Leray 27, 28, 29 C.-M. Loche C. Louapre 30 C. Lubetzki 31 A. Maarouf 4 B. Mada L. Magy 4 E. Maillart 32 E. Manchon R. Marignier 33 P. Marque G. Mathey 15 A. Maurousset C. Mekies M. Merienne 23 L. Michel 34 A.-M. Milor X. Moisset 35 A. Montcuquet T. Moreau N. Morel M. Moussa J.-P. Naudillon M. Normand P. Olive J.-C. Ouallet O. Outteryck C. Pacault C. Papeix 32 I. Patry 36 D. Peaureaux J. Pelletier 37 B. Pichon 38 S. Pittion E. Planque M.-C. Pouget V. Pourcher 39 C. Radot I. Robert F. Rocher A. Ruet 40 C. Saint-Val J.-Y. Salle A. Salmon E. Sartori S. Schaeffer B. Stankhof F. Taithe 41 E. Thouvenot 4 C. Tizon A. Tourbah 42 P. Tourniaire M. Vaillant 43 P. Vermersch 4 S. Vidil A. Wahab M.-H. Warter S. Wiertlewski 44 B. Wiplosz B. Wittwer C. Zaenker H. Zephir 4
1 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
2 Hosp Civils Lyon, Serv Malad Infect, Lyon, France
3 BGS - Biogéosciences [UMR 6282] [Dijon]
4 CRMBM - Centre de résonance magnétique biologique et médicale
5 CHU Montpellier
6 CHU Pontchaillou [Rennes]
7 CHU Saint-Etienne
8 CEMEREM - Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - AP-HM]
9 Comité de Développement Horticole du Centre Val de Loire (CDHRC)
10 GéPITOS - Génétique, physiopathologie et ingénierie du tissu osseux
11 SECM - Service d'Etudes du Comportement des Matériaux de Conditionnement
12 GEPI - Galaxies, Etoiles, Physique, Instrumentation
13 Service de Neurologie [Rennes]
14 ENT - Excitabilité nerveuse et thérapeutique
15 APEMAC - Maladies chroniques, santé perçue, et processus d'adaptation
16 RMN et optique : De la mesure au biomarqueur
CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
17 IEMN - Institut d’Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520
18 Combustion Research Facility
19 Service de Pédiatrie [Jean Verdier]
20 Kuriwa Observatory
21 Fondation Ophtalmologique Adolphe de Rothschild [Paris]
22 M2P2 - Laboratoire de Mécanique, Modélisation et Procédés Propres
23 IBCP - Institut de biologie et chimie des protéines [Lyon]
24 EuroMov - Euromov
25 U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie
26 UNS UFR Médecine - Université Nice Sophia Antipolis - Faculté de Médecine
27 REPERES - Recherche en Pharmaco-épidémiologie et Recours aux Soins
28 EHESP - École des Hautes Études en Santé Publique [EHESP]
29 METIS - Département Méthodes quantitatives en santé publique
30 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
31 Biologie des Interactions Neurones / Glie
32 Département de Neurologie [Paris]
33 CRNL - Centre de recherche en neurosciences de Lyon
34 CIC - Centre d'Investigation Clinique [Rennes]
35 Service de Neurologie, CHU Clermont-Ferrand
36 Hôpital Jean Minjoz
37 LAGEP - Laboratoire d'automatique et de génie des procédés
38 UL - Université de Lorraine
39 CHU Pitié-Salpêtrière [APHP]
40 Haras National Suisse
41 CHU Clermont-Ferrand
42 CHU Reims - Centre Hospitalier Universitaire de Reims
43 Center for health studies
44 Service de neurologie [Nantes]
Abstract : Objectives: To establish recommendations on immunization for patients with multiple sclerosis (MS).Background: Vaccines have been suspected in the past to trigger MS and relapses. With the extension of the immunoactive treatment arsenal, other concerns have been raised more recently about an increased risk of infection or a decreased effectiveness of immunization in immunosuppressed patients.Methods: The French Group for Recommendations into Multiple Sclerosis (France4MS) performed a systematic search of papers in Medline and other university databases (January 1975-June 2018). The RAND/UCLA appropriateness method was chosen to review the scientific literature and to formalize the degree of agreement among experts on 5 clinical questions related to immunization and MS. Readers from the steering committee conducted a systematic analysis, wrote a critical synthesis and prepared a list of proposals that were evaluated by a rating group of 28 MS experts. The final version of the recommendations was finally reviewed by a reading group of 110 health care professionals and classified as appropriate, inappropriate or uncertain.Results: Neurologists should verify the vaccination status as soon as MS is diagnosed and before disease-modifying treatments (DMTs) are introduced. The French vaccination schedule applies to MS patients and seasonal influenza vaccination is recommended. In the case of treatment-induced immunosuppression, MS patients should be informed about the risk of infection and the vaccination standards of the French High Council of Health should be applied. Live attenuated vaccines are contra-indicated in patients recently treated with immunosuppressive drugs, including corticosteroids; other vaccines can be proposed whatever the treatment, but their effectiveness may be partly reduced with some drugs.Conclusion: Physicians and patients should be aware of the updated recommendations for immunizations of patients with MS.
Keywords : Vaccine Prevention Immunization Infection Multiple sclerosis
Document type :
Journal articles
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https://hal.ehesp.fr/hal-02546158
Contributor : Scd Ehesp <>
Submitted on : Friday, April 17, 2020 - 5:14:19 PM
Last modification on : Wednesday, July 8, 2020 - 12:44:08 PM

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EHESP | REPERES | UNIV-RENNES1 | METIS-EHESP | UNIV-BOURGOGNE | HCL | OBSPM | EC-MARSEILLE | CRMBM | CHLS | ENT | M2P2 | CREATIS | UPEC-UPEM | UPEC | CIC | CEA | UNIV-LORRAINE | UNIV-ST-ETIENNE | UNIV-VALENCIENNES | UNIV-LYON1 | CIC203 | UR1-UFR-SVE | ICM | INSA-LYON | UNIV-MONTPELLIER | UNICE | UNIV-COTEDAZUR | UNIV-NANTES | UNIV-RENNES | UNIV-LILLE | CRTI | APEMAC-UL | LAGEP | UNIV-AMU | INSA-GROUPE | SORBONNE-UNIVERSITE | SU-MEDECINE | PSL | USPC | CNRS | UDL | UNIV-PARIS13 | BS | UNIV-PARIS7 | INSU | BIOSIT

Citation

C. Lebrun, S. Vukusic, V. Abadie, C. Achour, F. Ader, et al.. Immunization and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society. Revue Neurologique, Elsevier Masson, 2019, 175 (6), pp.341-357. ⟨10.1016/j.neurol.2019.04.001⟩. ⟨hal-02546158⟩

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