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Journal articles
The associations of earlier trauma exposures and history of mental disorders with PTSD after subsequent traumas
R. Kessler
S Aguilar-Gaxiola
J. Alonso
E Bromet
O Gureje
E Karam
K Koenen
S Lee
H. Liu
B-E Pennell
M Petukhova
N Sampson
V Shahly
D Stein
L Atwoli
G Borges
B Bunting
G de Girolamo
S Gluzman
J Haro
H Hinkov
N Kawakami
V. Kovess-Masféty
1, 2
F Navarro-Mateu
J Posada-Villa
K Scott
A Shalev
M ten Have
Y Torres
M. Viana
3
A. Zaslavsky
4
1
EHESP - École des Hautes Études en Santé Publique [EHESP] (15, avenue du Pr. Léon Bernard - 35043 Rennes Cedex - France)
2
METIS - Département Méthodes quantitatives en santé publique (15 avenue du Professeur Léon-Bernard - 35043 Rennes cedex - France)
- EHESP - École des Hautes Études en Santé Publique [EHESP] (15, avenue du Pr. Léon Bernard - 35043 Rennes Cedex - France)
3
Federal University of Espírito Santo (Campus Goiabeiras Vitória ES Brazil - Brazil)
4
HMS - Harvard Medical School [Boston] (25 Shattuck Street Boston, MA 02115 - United States)
Abstract : Although earlier trauma exposure is known to predict posttraumatic stress disorder (PTSD) after subsequent traumas, it is unclear whether this association is limited to cases where the earlier trauma led to PTSD. Resolution of this uncertainty has important implications for research on pretrauma vulnerability to PTSD. We examined this issue in the World Health Organization (WHO) World Mental Health (WMH) Surveys with 34 676 respondents who reported lifetime trauma exposure. One lifetime trauma was selected randomly for each respondent. DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) PTSD due to that trauma was assessed. We reported in a previous paper that four earlier traumas involving interpersonal violence significantly predicted PTSD after subsequent random traumas (odds ratio (OR)=1.3-2.5). We also assessed 14 lifetime DSM-IV mood, anxiety, disruptive behavior and substance disorders before random traumas. We show in the current report that only prior anxiety disorders significantly predicted PTSD in a multivariate model (OR=1.5-4.3) and that these disorders interacted significantly with three of the earlier traumas (witnessing atrocities, physical violence victimization and rape). History of witnessing atrocities significantly predicted PTSD after subsequent random traumas only among respondents with prior PTSD (OR=5.6). Histories of physical violence victimization (OR=1.5) and rape after age 17 years (OR=17.6) significantly predicted only among respondents with no history of prior anxiety disorders. Although only preliminary due to reliance on retrospective reports, these results suggest that history of anxiety disorders and history of a limited number of earlier traumas might usefully be targeted in future prospective studies as distinct foci of research on individual differences in vulnerability to PTSD after subsequent traumas.
Keywords :
Trauma exposures
Mental disorders with PTSD
Document type :
Journal articles
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https://hal.ehesp.fr/hal-02466343
Contributor : Scd Ehesp <>
Submitted on : Tuesday, February 4, 2020 - 2:04:44 PM
Last modification on : Tuesday, November 10, 2020 - 4:48:56 PM
Contributor : Scd Ehesp <>
Submitted on : Tuesday, February 4, 2020 - 2:04:44 PM
Last modification on : Tuesday, November 10, 2020 - 4:48:56 PM
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- HAL Id : hal-02466343, version 1
- DOI : 10.1038/mp.2017.194
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R. Kessler, S Aguilar-Gaxiola, J. Alonso, E Bromet, O Gureje, et al.. The associations of earlier trauma exposures and history of mental disorders with PTSD after subsequent traumas. Molecular Psychiatry, Nature Publishing Group, 2018, 23 (9), pp.1892-1899. ⟨10.1038/mp.2017.194⟩. ⟨hal-02466343⟩
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