Psychotic experiences and general medical conditions: a cross-national analysis based on 28 002 respondents from 16 countries in the WHO World Mental Health Surveys - Archive ouverte HAL Access content directly
Journal Articles Psychological Medicine Year : 2018

Psychotic experiences and general medical conditions: a cross-national analysis based on 28 002 respondents from 16 countries in the WHO World Mental Health Surveys

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Sukanta Saha
  • Function : Author
Carmen C.W. Lim
  • Function : Author
Sergio Aguilar-Gaxiola
  • Function : Author
Ali Al-Hamzawi
  • Function : Author
Evelyn Bromet
  • Function : Author
  • PersonId : 908893
Giovanni de Girolamo
  • Function : Author
  • PersonId : 908897
Louisa Degenhardt
  • Function : Author
Silvia Florescu
  • Function : Author
Oye Gureje
Josep Haro
  • Function : Author
Chiyi Hu
  • Function : Author
  • PersonId : 908900
Sing Lee
  • Function : Author
Jean-Pierre Lépine
  • Function : Author
Zeina Mneimneh
  • Function : Author
Fernando Navarro-Mateu
  • Function : Author
Marina Piazza
  • Function : Author
Jose Posada-Villa
  • Function : Author
  • PersonId : 908910
Nancy Sampson
  • Function : Author
  • PersonId : 908896
Juan Carlos Stagnaro
  • Function : Author
Ronald Kessler
  • Function : Author
  • PersonId : 908913
John Mcgrath

Abstract

BACKGROUND: Previous work has identified associations between psychotic experiences (PEs) and general medical conditions (GMCs), but their temporal direction remains unclear as does the extent to which they are independent of comorbid mental disorders. METHODS: In total, 28 002 adults in 16 countries from the WHO World Mental Health (WMH) Surveys were assessed for PEs, GMCs and 21 Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) mental disorders. Discrete-time survival analyses were used to estimate the associations between PEs and GMCs with various adjustments. RESULTS: After adjustment for comorbid mental disorders, temporally prior PEs were significantly associated with subsequent onset of 8/12 GMCs (arthritis, back or neck pain, frequent or severe headache, other chronic pain, heart disease, high blood pressure, diabetes and peptic ulcer) with odds ratios (ORs) ranging from 1.3 [95% confidence interval (CI) 1.1-1.5] to 1.9 (95% CI 1.4-2.4). In contrast, only three GMCs (frequent or severe headache, other chronic pain and asthma) were significantly associated with subsequent onset of PEs after adjustment for comorbid GMCs and mental disorders, with ORs ranging from 1.5 (95% CI 1.2-1.9) to 1.7 (95% CI 1.2-2.4). CONCLUSIONS: PEs were associated with the subsequent onset of a wide range of GMCs, independent of comorbid mental disorders. There were also associations between some medical conditions (particularly those involving chronic pain) and subsequent PEs. Although these findings will need to be confirmed in prospective studies, clinicians should be aware that psychotic symptoms may be risk markers for a wide range of adverse health outcomes. Whether PEs are causal risk factors will require further research.

Dates and versions

hal-02465870 , version 1 (04-02-2020)

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Cite

Kate Scott, Sukanta Saha, Carmen C.W. Lim, Sergio Aguilar-Gaxiola, Ali Al-Hamzawi, et al.. Psychotic experiences and general medical conditions: a cross-national analysis based on 28 002 respondents from 16 countries in the WHO World Mental Health Surveys. Psychological Medicine, 2018, 48 (16), pp.2730-2739. ⟨10.1017/S0033291718000363⟩. ⟨hal-02465870⟩
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