High-dose biotin in progressive multiple sclerosis: A prospective study of 178 patients in routine clinical practice

Abstract : Background: A recent controlled trial suggested that high-dose biotin supplementation reverses disability progression in patients with progressive multiple sclerosis. Objective: To analyze the impact of high-dose biotin in routine clinical practice on disability progression at 12 months. Methods: Progressive multiple sclerosis patients who started high-dose biotin at Nantes or Rennes Hospital between 3 June 2015 and 15 September 2017 were included in this prospective study. Disability outcome measures, patient-reported outcome measures, relapses, magnetic resonance imaging (MRI) data, and adverse events were collected at baseline, 6, and 12 months. Results: A total of 178 patients were included. At baseline, patients were 52.0 ± 9.4 years old, mean Expanded Disability Status Scale (EDSS) score was 6.1 ± 1.3, mean disease duration was 16.9 ± 9.5 years. At 12 months, 3.8% of the patients had an improved EDSS score. Regarding the other disability scales, scores either remained stable or increased significantly. In total, 47.4% of the patients described stability, 27.6% felt an improvement, and 25% described a worsening. Four patients (2.2%) had a relapse. Of the 74 patients (41.6%) who underwent an MRI, 20 (27.0%) had new T2 lesions, 8 (10.8%) had gadolinium-enhancing lesions. Twenty-five (14%) reported adverse event. Conclusion: In this study, high-dose biotin did not seem to be associated with a clear improvement in disability.
Document type :
Journal articles
Complete list of metadatas

https://hal.ehesp.fr/hal-02436685
Contributor : Scd Ehesp <>
Submitted on : Monday, January 13, 2020 - 12:01:12 PM
Last modification on : Sunday, January 19, 2020 - 1:02:29 AM

Identifiers

Citation

Laura Couloume, Laetitia Barbin, Emmanuelle Leray, Sandrine Wiertlewski, Emmanuelle Le Page, et al.. High-dose biotin in progressive multiple sclerosis: A prospective study of 178 patients in routine clinical practice. Multiple Sclerosis Journal, SAGE Publications, 2019, pp.135245851989471. ⟨10.1177/1352458519894713⟩. ⟨hal-02436685⟩

Share

Metrics

Record views

22